Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of wellbeing. Depressed people feel sad, anxious, empty, hopeless, worried, helpless, worth guilty, irritable, hurt, or restless. They may lose interest in activities that once were pleasurable, experience loss of appetite or overeating, have problems concentrating, remembering details, or making decisions, and may contemplate, attempt, or commit suicide, loss of energy, or aches, pains, or digestive problems that are resistant to treatment may also be present. Homeopathy probes much deeper level to understand triggers and cause. Individual disposition, environment, perception and belief system are taken into consideration before prescribing homoeopathic remedy. Remedies are prescribed after detail case history. Remedies prescribed for depression few of them like Sepia, Nat-Mur, Aur-Met, etc